Biosynthesis
Coenzyme Q-10 can be synthesized by the body in almost all of the cells. It is an important component of mitochondria. The building block for Co Q-10 is an amino acd tyrosine or phenylalanine which becomes synthesized to benzoquinone. This step requires vitamin B6 as a cofactor hence low vitamin B6 in a diet might interfere with production of Co Q-10. Further synthesis involves creation of isoprenoid side chain from Acetyl CoA. Finally with a help HMG CoA reductase enzyme these two structures become synthesized to ubiquinone (other name for Co Q-10).
References
Meredith Spindler, M Flint Beal, Claire Henchcliffe. Coenzyme Q10 effects in neurodegenerative disease. Dove Press Journal: Neuropsychiatric Deasease and Treatment, November 6, 2009. p. 597-610
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| Synthesis of Coenzyme Q10 |
References
S. Shinde, N. Patil & A. Tendolkar: Coenzyme Q10: A Review of Essential Functions. The Internet Journal of Nutrition and Wellness. 2005 Volume 1 Number 2
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